I think I've suggested this before, but I thought up some more things that might be useful:
It would be fun, I think, if we could have room maintenance be based at least a little on what we know about said room, like the laboratory not being a huge drain on your funds until after you figure out how turn the mainframe on. This would allow us to start with an even smaller amount of monthly funds.
Further, IF it's possible, having research sort of upgrade the room could be nice, like the starting laboratory only having room for 5 brainers, perhaps due to clutter, or the capacity to eventually set up a cloning facility in the surgery, or whatever. We could have requirements of whatever items you would logically need to actually do the upgrade for you to even start these research projects. Plugging in the mainframe is relatively easy, perhaps requiring superconducting wire, as is clearing out the built up junk, but making a cloning facility would require at least one cloning tank, making a workshop better would require an industrial scanner, and turning an old-fashioned prison into a high-tech cold storage (which might not even have a max space) would require lots of stasis pods.
On cloning, I assume it would boost healing, having suitable replacements for damaged pieces, but it could also maybe allow you to grow clones of dead gals, with minor stat damage.
And since every post here has to be about the weather for some reason
Is it possible to have the weather based on tile set instead of whole map? Like inside a ship there should be no weather effects, though there might be environmental effects, inside normal buildings cold doesn't do anything but heat can, caves would be like ships, and ruins provide no shelter?
...These would probably all be quite a bit of work, but I hope they're good ideas possibly worth the effort.
Edit
To slightly clarify what I was thinking with the weather, the map could have marked what weathers it wants, and the specific tiles, if they had a weather that fit, would have that in them, possibly accounting for ambient light, to account for areas that have extremely different weather depending on sunlight, though that is likely to be too complicated. so desert town, daytime, would have heat outdoors, maybe lessened heat in normal buildings, and ones that reasonably would be air conditioned, would be comfortable