I like the weather, despite or maybe because it's hard, I actually wanted to suggest more weather: low background radiation, which would cause ubers who knows what sorts of problems, as well as high background radiation, providing bonuses to those with uber physiology, both player and not player. extreme storms could be fun too, very low visibility and weapon range way down, muscle and spring powered weapons unreliable in the extreme.
I'm worried about the mansion issues because I'm actually not very good at this game, But I don't want to argue about the timer until I see where it starts.
Here's a possible idea for the mansion though: have some secondary exit points, maybe by outside walls or sewer grates or something, in case your gals are far from the roof, they can bug out properly and be picked up outside.