I wonder if I should try using flintlock pistols like handles in the early game, they're less accurate but do normal damage through armor whereas the handle would do less damage through armor. At least that's what the ANAL button says.
That does bring up another question, though. Can melee reaction attacks be done with items with secondary melee options (like the aye-phone or flintlock pistol, preferably unloaded so you don't shoot instead)?