Looking at bootypedia, fusion ball launchers do more than double damage rate of hammermite, plus they won't run out of clips, and have 60 range so even modest shielding allows hit and run, so definitely possible eventually.
(edited out some stupid ideas)
Actually, a barracuda tank (300 shielding) + 3 brave whalers with avalanches (9 total) might be able to do hit and runs without repairing, due to the range and avalanches doing their damage all at once. But this all seems kinda pointless since you're dedicating all of your hangar space just to take something out early that you don't need to. Infamy loss is less than a science vessel, so it's only worth doing if you plan on assaulting it, which from what I've heard is a serious PITA.
The best tank is probably shadowteched shadowcraft or menace ships. But you'd need ethyr orbs or a fast menace and fusion drives. Sounds like gold codex has an advantage here, since a hawk/el fuego can throw together any random orbs you find and still have some shielding.
Edit: btw, anyone know how psionics works in x-piratez? In vanilla, psi panic does 110-bravery morale damage, but your gals can reach 110 bravery. Is there a minimum bravery loss to panic? And if not, will the enemy then just immediately go for mind control if you have high bravery?