Sure.
I'll try to list my favourite early weapons. (Some of them very early, some not so, but generally before lasers.)
For pistols, I think Manstopper is my favourite (especially with EP munitions, but that's not exactly early). It's reliable and has enough kick. Just don't try to harass people wearing plastasteel armour with it.
The best SMG is definitely Blackmarch. It is very accurate and has decent damage, for an SMG. Seems to be a tech level above all else. But I've used Assault SMG with good results, too.
Shotguns? I don't use them that much. The Blunderbuss is absolutely devastating, but a bit too specialized for my taste.
If we're talking assault rifles, then Battle Rifle is a good all-rounder - it's basically vanilla rifle on steroids. But it is IMO overshadowed by the Autogun, which is very accurate, light and pretty strong, with good range. And then there's the Linux Mandrake/Origami, which is even better in most respects.
Sniper rifles are all useful. Special mention goes to the Hunting Rifle/Scoped Rifle as a good, cheap weapon for inept swabbies (they won't do much, but at least they'll be hitting and scoring experience).
Heavy weapons? Now that's more complicated, since they have many different roles to fill:
- I would say Boarding Gun is better than people say, but it is best at relatively short ranges, at full auto. And its descendant, the Custom Shooty Gun, is pure poetry.
- Spitfire and LACC are great at killing lightly-armoured targets and generally causing havoc, due to their explosive ammo.
- The HMG is quite awesome, but IMO it requires a flying gal to use it effectively. It also shines on some maps (like Ratman Rodeo) and is next to useless on others (base assault/defence).
- The LMG is more like a specialized Battle Rifle than a typical heavy weapon. It is surprisingly effective.
- RPG and Panzerfaust: used to be absolutely essential in older versions, but now you just don't meet powered armours and Cyberdiscs on a regular basis. Still, if you do...
Melee weapons: Rapier, Cutlass, Sabre and Axe are all relevant, since each is designed for a different set of stats. Daggers are more of backup weapons (some types are quite good in the right hands, but I'd rather give them Axes).
Stun melee weapons: Fisticuffs for the strong and skilful, Handles for the strong and brave, Electric Clubs for the plebs. Cattle Prods are way too unwieldy for me.
Explosives: all are useful and have their roles.