It will change how they use it to the extent that blaster launcher like weapons have their own case when the AI is deciding to do an attack with it. This is mostly because they can use the flags of a recently "spotted" x-com unit, as they do with psionic attacks, to target said unit using waypoints. Without the ability to use the waypoints, they would use it as they do with other armaments, only targetting units they can directly see themselves, and due to the blast radius, they could get caught in it if they do choose to fire it, depending on distance.