So you can basicly lose to RNG events and lack of good missions due to negative infamy?
Yes and no. Yes because its possible, no because its so absurdly hard to lose that way that you'll prob just get killed way before you have any chance to lose due to low infamy. The new random events don't affect your infamy enough to actualy harm you in any significant way. Actualy, the most annoying random event I've got is the fungus infestation one.
Here's a tip: Keep yourself finantialy afloat and dont do pogroms until you research *the mutant alliance*. Before that point, pogroms are completely optional and won't generate bad score if you ignore them. If you do try and fail a pogrom however, thats about -500 or worse infamy. Also, keep your research going and get more brainers, as research is actualy the very best source of infamy for a looooooong time.
After 10 or so runs spread across 5 or 6 different versions, I've never had a game in which my score was at risk due to lack of good missions. Mission variety has increased a lot in the last releases, meaning its even harder to have a run in which you get no good missions.