On the previous game I had going I had my first base down to just one hangar eventually, to accommodate all the research buildings as well as enough storage for all the stuff I was getting on missions. Second base I'd set up to get ready for a factory . . . I'm not doing that again, because I was still nowhere near getting the factory ready to build, but that will come at a later point eventually. My third, which this time around will be my second, I set up with a Large Prison and a Luxury Spa, not only to be a repository for my Courtesans, but also to be a training ground for new recruits, so they wouldn't end up going into battle too weak to handle at the things my main gals could do with ease.
The plan was, and still is, to end up having 2 or 3 bases that are dedicated to housing M-Wing interceptors, so I can at mid- and late-game easily shoot down any enemy vessel in the air, to stop the Guild, Academy, Church, Mercenaries, and such from becoming too much of a pain. In all of them I will have at least one prison, and at least 10 gals, eventually more I'm sure, to provide base defense if nothing else. Anything that can will have gals going out, but I don't know if my M-Wing bases will really be able to do that effectively. We'll see.
All of this I expect to take 3 game years or more to get to the point of having the prison, dedicated manufacturing, and at least a couple interceptor bases on top of my starting base. I probably won't even have a second base started in the first year. I've had a few times I got to it as soon as I could 'afford' it and then it only takes a couple months to find out . . . no I can't.