now that we have this topic, perhaps we should use it as a rallying point? @Tripp: would you be willing to install a list of hotkeys in your first post that you update as we go along?
I think the "w a s d" keys shouldn't be used for hotkeys other than "left down right up", because that is kind of a convention: use either "arrow keys" or "w a s d". the new UFO:EU uses "w a s d" and most other hotkeys are laid out around that... maybe something like that would work for us, too?
I think "q" and "e" should be reserved for "rotate viewscreen left / right" in case we ever implement that.
"f" could be "fire", maybe "f" "g" "h" for the three available firing modes? ("f" for fire a.k.a. snap shot / "g" for "gun 'em down!" a.k.a. auto fire / "h" for high accuracy a.k.a. aimed shot)
"t" for throw? it's close to the other keys, but one row up, so no accidentally throwing your large plasma at the sectoid...
"r" for priming grenades, because it's next to the "throw" button? when priming mode is on, pressing "r" again sets timer to "0", so you don't have to move your hand for the most-used setting ("esc" exits priming mode)?