As far as I'm aware, rope is just for putting them on the ground, it's very effective against anything that breathes and isn't in power armor but takes a lot of TU to use. I'd have to check, but I think using manacles in combat is just swinging them into your enemy, their main use is to use them while standing on a downed enemy, removes the manacles and increases stun a lot. However, high stun has a chance of just damaging the target, eventually killing them, so it's risky.
Incidentally, you using a phone to post? Cause I remember you being better at spelling