I like 3D openxcom which will look like on screenshot. Cartoon-like proportion of creature is charming, as familiar textures of ufo walls.
I don't like if it will overuse possibilities of 3D, like camera free-flying. I think it should use 3D very accurate, to keep whole design and style consistent and solid.
Though, fake-occlution shading I prefer more, than real-shading (it makes battlefield appearing like a chessboard). Also although I don't like "shaders" much, I'd like to see "neat" shaders, on the water, glass or metallic objects. It will grow feeling of "solidness" and reality of battlescape environment.
So I think there should be "toyness" design, a balance between "reality" and "cartoon".