While I do not remember exact enemy count I did my first mansion mission yesterday. It took over 2 hours to clear the whole place, partly due to my only thinking of using rippers after an hour and a half. I took the approach of splitting into teams of 2-5 depending on which floor i was clearing and started on the bottom working my way up via the big staircases and ended it after turn 35 on putting down the last Osiron Yeoman. For me much of the difficulty came from the fact that I had several leakers who got past my gals using the small stairs and then decided to hide on floors that I thought were clear. Took my best squad of vets with plenty of missions and Dojo time. I don't have access to any armors that are on the approved attire list so I went in with one gal in the Seductress outfit for dealing with any heavy hitters as I found that a very effective way of dealing with power armor before I had decent weapons and assumed that there would be at least some armored opposition. The rest of the hands were using the free maid outfits with ranged focused hands firing shiny new smartpistols, new vibrablades for melee troops and anyone with throwing over 50 got a blowgun with one reload due to the armor ignore mechanic. Looking back this was well more than what was actually needed for the mission as it stands now.
Next time through I will probably head for one much sooner mainly waiting till I have Rippers and a decent supply of vodka though there is plenty inside already. Regarding playing this as a smash and grab I noticed 2 rooms on in the basement that each have one entrance and one of the treasure items (money pouch etc.) as the only item in the room. Were I doing this and things started to go south I would likely send my 2 fastest runners after those while the rest covered the evac route to the roof then leapfrog back and scurry away. This wouldn't be anywhere near the haul for a full clear but would likely be doable from day 1 with a little luck and rotating back wounded hands while you hold the stairs for the runners though I would certainly use a small pile of smoke if I was trying this as an early game rush. I feel that the difficulty was good for when I first got the option to do the mission but it was still a nice challenge and a good change of pace to be forced to fight without advanced armor again. The overall feel was much like the first few ships I knocked off after they landed, A group of effectively naked savages with cobbled together firearms and primitive weaponry against an enemy who had firearms and a decent position.
Oh and it certainly is the map from hell